It is necessary to have at least TCP port 443 open.
Opening UDP port 3478 is not necessary but recommended in order to obtain better quality.
For the best possible experience, opening UDP ports 1025-65535 is recommended.
It works well with most proxies and VPN.
Vonage Video API shares an open source application which will tell you if the connected network is webRTC compatible. The application also identifies line quality and system configuration when doing a WebRTC call like Remote eye. Link
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